Faculty Profile

Dr. Carina Howell

chowell@lhup.edu | 208 Science Center, Lock Haven, PA 17745 | (570) 484-2369

For additional information, please click here.

Education: 

Ph.D. Biology, University of Pittsburgh (2000)

B.S. Biology, The Pennsylvania State University (1995)

Courses Most Commonly Taught: Genetics, Human Genetics, Developmental Biology, Bioinformatics and Genomics, Basic Biology, Advanced Applied Nanotechnology Laboratory

Courses Developed: Human Genetics, Bioinformatics and Genomics 

Professional Publications:

Shaffer, D., … Howell, C.E. …Elgin, S.C.R.. (2013) A Course-Based Research Experience: How Benefits Change with Increased Investment in Instructional Time. Submitted for publication.

Seacor, T., Striluk, M., and Howell, C.E. (2013) Classification of Wild Isolate Nematode Strains Using Classical Systematics and Molecular Sequencing. Submitted for publication.

Howell, C.E. and Howell, J.E. (2010) Sectioning clay models makes anatomy and development tangible. American Biology Teacher 72:313–14.

Howell, C.E. (2010) Experimental HIV Vaccine. Magill’s Medical Guide. 6th ed. Pasadena, Calif.: Salem Press. 1519.

Howell, C.E. (2010) Model organism: Danio rerio. Genetics and Inherited Conditions. Pasadena, Calif.: Salem Press. 825–27.

Campanella, J.J., Ness, B. and Howell, C.E. (2010) Cloning: Ethical Issues. Genetics and Inherited Conditions. Pasadena, Calif.: Salem Press. 272–76.

Dong, L., Chen, Y., Lewis, M., Hsieh, J.C., Reing, J., Chaillet, J R., Howell, C.Y., Melhem, M., Inoue, S., Kuszak, J.R. DeGeest, K., and Chung, A.E. (2002) Neurologic defects and selective disruption of basement membranes in mice lacking entactin-1/nidogen-1. Lab Invest 82:1617–30.

Ratnam, S., Mertineit C., Ding F., Howell, C.Y., Clarke, H.J., Bestor T.H., Chaillet J.R., and Trasler, J.M. (2002)  Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development. Develop Bio 245:304–14.

Howell, C.Y., Bestor T.H., Ding F., Latham K.E., Mertineit C., Trasler J.M., and Chaillet, J. R. (2001)  Genomic imprinting disrupted by a maternal-effect mutation in the Dnmt1 gene. Cell 104:829–38.

Shuster, M., Dhar, M.S., Olins, A.L., Olins, D.E., Howell, C.Y., Gollin, S.M., and Chaillet, J.R. (1998) Parental alleles of an imprinted mouse transgene replicate synchronously. Develop Genet 23:275–284.

Howell, C.Y., Steptoe, A.L., Miller, M.W., and Chaillet, J.R. (1998) cis-Acting signal for inheritance of imprinted DNA methylation patterns in the preimplantation mouse embryo. Mol Cell Biol 18:4149–56.

Seibert, S.A., Howell, C.Y., Hughes, M.K., and Hughes, A.L. (1995) Natural selection on the gag, pol, and env genes of human immunodeficiency virus 1 (HIV-1). Mol Biol Evol 12:803–13.

Hughes, A.L., Hughes, M.K., Howell, C.Y., and Nei, M. (1994) Natural selection at the class II major histocompatibility complex loci of mammals. Philos Trans R Soc Lond 346: 359–66.

 Professional Presentations:

Howell, C.E., Seacor, T., and. Striluk, M., (2013) Exploiting Nematode Diversity to Teach Advanced Techniques in Bioinformatics, Molecular Evolution and Fluorescence and Electron Microscopy.17th International Congress of Developmental Biology, Cancun, Mexico.

Howell, C.E. (2013) Inquiry-based Instruction in an Undergraduate Bioinformatics Course Leads to Novel Publishable Results with the Genomics Education Partnership, 3rd Annual Undergraduate Bioinformatics Education Conference, Saint Vincent College.

Howell, C.E. and W. Hanna-Rose (2012) Affordable Research Opportunities for Undergraduates: an RNAi Screen to Identify Genes Involved in C. elegans Vulva Morphogenesis. Society for Developmental Biology Mid-Atlantic Regional Meeting. The Pennsylvania State University.

Howell, C.E. (2010) Sectioning Clay Models makes Anatomy and Development Tangible. 41st Annual meeting of the Commonwealth of Pennsylvania University Biologists. East Stroudsburg University.

Howell, C.E. (2009) Integrating Laptops in the Genetics Laboratory through the use of Bioinformatics Databases. 40th Annual meeting of the Commonwealth of Pennsylvania University Biologists. Lock Haven University.

Howell, C.E. (2008)  Independent Student Research Integrated in a Laboratory Course: Chick Teratogenesis in Developmental Biology. 39th Annual meeting of the Commonwealth of Pennsylvania University Biologists. Shippensburg University.

Howell, C.E. (2006) The Nose Knows:  How Olfactory Neurons Regenerate. Slippery Rock University, Slippery Rock, PA.

Howell, C.Y., Yang, Y.H., Vranizan, K., Speed, T., and J. Ngai. (2004) Analysis of gene expression during development and regeneration of the olfactory system. Molecular and Cellular Neurobiology, Gordon Research Conference, Hong Kong, China.

Howell, C.Y., Yang, Y.H., and J. Ngai. (2003) Analysis of gene expression during development and regeneration of the olfactory system. Developmental Supergroup, Berkeley, CA.

Howell, C.Y., Yang, Y.H., and J. Ngai. (2003) Analysis of gene expression during development and regeneration of the olfactory system. UC Berkeley Neuroscience Retreat, Lake Tahoe, CA.

Howell, C.Y., and J. Ngai. (2002) Analysis of gene expression during neuronal regeneration in the olfactory system. UC Berkeley Neuroscience Retreat, Lake Tahoe, CA.

Howell, C.Y., and J.R. Chaillet. (1999) Genomic imprinting disrupted by a maternal-effect mutation in the Dnmt1 gene. Biological Sciences Retreat, Pymatuning, PA.

Howell, C.Y., Fan, Y., and J.R. Chaillet. (1997) Selective maintenance of methylation in the generation of imprinted genes. Gordon Conference on Epigenetics, Plymouth, NH.

Howell, C.Y., Steptoe, A.L., Miller, M.W., and J.R. Chaillet. (1997) Selective maintenance of methylation in the generation of imprinted genes. Pittsburgh Cancer Institute Retreat, Johnstown, PA.

Howell, C.Y., Hughes, M.K., and A.L. Hughes. (1994) Natural selection at the class II major histocompatibility complex loci of mammals. Eastern Great Lakes Molecular Evolution Meeting, Rochester, NY.

 Areas of Expertise: Genetics, Molecular Biology, Evolutionary Developmental Biology, Neurodevelopment, Bioinformatics and Genomics

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